• Mayra A Dantés-Durán, Edmundo E Castelán-Maldonado, and Gerardo Del C Palacios-Saucedo.
• Departamento de Anatomía Patológica, Unidad Médica de Alta Especialidad Hospital de Especialidades 25, Instituto Mexicano del Seguro Social, Monterrey, México.
• Gac Med Mex. 2023 Mar 1.

BackgroundProstate carcinoma is the second leading cause of cancer and the fifth cause of cancer death in men worldwide.ObjectiveTo know high-grade prostatic intraepithelial neoplasia and prostate acinar adenocarcinoma immunohistochemical profiles.Material And MethodsObservational, analytical, cross-sectional, retrospective study of specimens obtained by cutting needle biopsy and prostate resection from subjects diagnosed with acinar adenocarcinoma of the prostate and high-grade prostatic intraepithelial neoplasia between January 2015 and December 2020. Tissue microarrays were performed and, subsequently, immunohistochemical studies for BCL2, EGFR, p53, Her2/neu and Ki67. Descriptive statistics were used to analyze clinicopathological factors. Qualitative variables were compared with Fisher's exact test.ResultsTwenty-three patients were studied; eight (34%) with angiolymphatic invasion, 14 (60.8%) with perineural invasion, five (21.2%) with prostatitis, and four (17.3%) with fibroadenomatous hyperplasia. HER2/neu (p = 0.1023), p53 (p = 1) and BCL2 expression (p = 0.4136) was observed.ConclusionHER2/neu increased expression was identified in high-grade prostatic intraepithelial neoplasia and acinar adenocarcinoma of the prostate.

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