• Qin-Qin Luo and Na-Na Luo.
• Traditional Chinese Medicine Department of Wuhan No.1 Hospital, China.
• Medicine (Baltimore). 2023 Mar 3; 102 (9): e33131e33131.

RationaleMetaplastic breast cancer (MBC) is a rare tumor of the breast, and skin ulceration of breast tumors is a difficult clinical problem that reduces the patient's quality of life.Patient ConcernsThere are currently no Standard Treatment Guidelines for MBC at present, and the treatment for the skin ulceration of breast tumors is limited in clinics.DiagnosisHere, we report the case of a patient with a large MBC and skin ulceration, accompanied by exudation and odor.InterventionThe combined treatment of albumin paclitaxel and carrelizumab (anti-PD-1 immunotherapy) was effective in reducing the tumor, but it increased the severity of the skin ulceration. After taking traditional Chinese medicine, the skin ulceration healed completely. Then the patient underwent a mastectomy and radiotherapy.OutcomesThe patient has a high quality of life and was in good condition after the comprehensive treatment.LessonsThis suggests that traditional Chinese medicine may have a good auxiliary therapeutic effect on the skin ulceration of MBC.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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