• Alejandro A Rabinstein, Raphael Cinotti, and Julian Bösel.
• Department of Neurology, Mayo Clinic, Rochester, MN, USA. rabinstein.alejandro@mayo.edu.
• Neurocrit Care. 2023 Apr 1; 38 (2): 439446439-446.

AbstractLiberating patients with severe traumatic brain injury (TBI) from mechanical ventilation is often a challenging task. These patients frequently require prolonged ventilation and have persistent alterations in the level and content of consciousness. Questions about their ability to protect their airway are common. Pulmonary complications and copious respiratory secretions are also very prevalent. Thus, it is hardly surprising that rates of extubation failure are high. This is a major problem because extubation failure is associated with a host of poor outcome measures. When the safety of an extubation attempt is uncertain, direct tracheostomy is favored by some, but there is no evidence that this practice leads to better outcomes. Current knowledge is insufficient to reliably predict extubation outcomes in TBI, and practices vary substantially across trauma centers. Yet observational studies provide relevant information that must be weighted when considering the decision to attempt extubation in patients with head injury. This review discusses available evidence on liberation from mechanical ventilation in TBI, proposes priorities for future research, and offers practical advice to guide decisions at the bedside.© 2023. Springer Science+Business Media, LLC, part of Springer Nature and Neurocritical Care Society.

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