• Internal medicine · May 2023

    Case Reports

    IgG4-related Disease Emerging after COVID-19 mRNA Vaccination: A Case Report.

    • Satsuki Aochi, Masaaki Uehara, and Motohisa Yamamoto.
    • Department of Rheumatology and Allergy, IMSUT Hospital, the Institute of Medical Science, the University of Tokyo, Japan.
    • Intern. Med. 2023 May 15; 62 (10): 154715511547-1551.

    AbstractA 78-year-old Japanese woman with no history of rheumatic disease received 2 doses of the BNT162b2 COVID-19 mRNA vaccine. Two weeks later, she noticed bilateral swelling in the submandibular region. Blood tests showed hyper-immunoglobulin (Ig)G4emia, and 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) revealed the strong accumulation of FDG in the enlarged pancreas. She was diagnosed with IgG4-related disease (IgG4-RD) according to the American College of Rheumatology (ACR)/the European League Against Rheumatism (EULAR) classification criteria. Treatment was started with prednisolone at 30 mg/day, and the organ enlargement improved. We herein report a case of IgG4-RD that may have been associated with an mRNA vaccine.

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