• Julia Bassell-Hawkins, Nina E Suresh, David Mahoney, Maïté Van Hentenryck, Alexandra Csortan, Diana Pena, and David N Cornfield.
• Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA. Electronic address: jbassell@stanford.edu.
• Chest. 2023 Mar 1; 163 (3): e107e110e107-e110.

AbstractFat embolism syndrome describes a constellation of symptoms that follow an insult and that results in a triad of respiratory distress, neurologic symptoms, and petechia. The antecedent insult usually entails trauma or orthopedic procedure, most frequently involving long bone (especially the femur) and pelvic fractures. The underlying mechanism of injury remains unknown but entails biphasic vascular injury with vascular obstruction from fat emboli followed by an inflammatory response. We present an unusual case of a pediatric patient with acute onset of altered mental status, respiratory distress, hypoxemia, and subsequent retinal vascular occlusions after knee arthroscopy and lysis of adhesions. Diagnostic findings most supportive of the fat embolism syndrome included anemia, thrombocytopenia, pulmonary parenchymal, and cerebral pathologic findings on imaging studies. This case highlights the importance of fat embolism syndrome as a diagnostic consideration after an orthopedic procedure, even absent major trauma or long bone fracture.Copyright © 2022 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

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