• Stefan Dugalic, Milica Petronijevic, Demet Sengul, Dzenana A Detanac, Ilker Sengul, Eduardo Carvalho de Arruda Veiga, Tamara Stanisavljevic, Maja Macura, Jovana Todorovic, and Miroslava Gojnic.
• University Clinical Center of Serbia, Clinic for Gynecology and Obstetrics - Belgrade, Serbia.
• Rev Assoc Med Bras (1992). 2023 Jan 1; 69 (2): 335340335-340.

ObjectiveOur study purposed to examine the complex relationship between low-molecular-weight heparin therapy, multiple pregnancy determinants, and adverse pregnancy outcomes during the third trimester in women with inherited thrombophilia.MethodsPatients were selected from a prospective cohort of 358 pregnant patients recruited between 2016 and 2018 at the Clinic for Obstetrics and Gynecology, University Clinical Centre of Serbia, Belgrade.ResultsGestational age at delivery (β=-0.081, p=0.014), resistance index of the umbilical artery (β=0.601, p=0.039), and D-dimer (β=0.245, p<0.001) between 36th and 38th weeks of gestation presented the direct predictors for adverse pregnancy outcomes. The model fit was examined using the root mean square error of approximation 0.00 (95%CI 0.00-0.18), the goodness-of-fit index was 0.998, and the adjusted goodness-of-fit index was 0.966.ConclusionThere is a need for the introduction of more precise protocols for the assessment of hereditary thrombophilias and the need for the introduction of low-molecular-weight heparin.

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