• Yu-Chien Tsao, Yen-Feng Wang, Jong-Ling Fuh, Wei-Ta Chen, Kuan-Lin Lai, Hung-Yu Liu, Shuu-Jiun Wang, and Shih-Pin Chen.
• Keelung Hospital of the Ministry of Health and Welfare, Keelung, Taiwan, ROC.
• J Chin Med Assoc. 2023 Jun 1; 86 (6): 557564557-564.

BackgroundTo investigate the characteristics and clinical correlates of transient visual disturbances (TVDs) in patients with migraine without aura (MO). Patients with MO frequently report TVDs, which differ from typical visual aura, but the clinical significance of these TVDs has not been determined.MethodsPatients with MO who attended our headache clinics were enrolled. Structured questionnaires were used to acquire data on participants' headache profiles, disability, comorbidities, and lifetime suicidal ideation and suicide attempts. A semistructured visual phenomenon questionnaire was used to characterize TVDs. Headache specialists interviewed the participants for diagnosis and the verification of questionnaire responses.ResultsPatients with MO (n = 7200; female/male ratio = 3.56, mean age 40.1 ± 13.4 years) were divided into two groups based on the presence (n = 2488) or absence (n = 4712) of TVDs. Patients with TVDs had more headache-related disability, psychiatric comorbidities, and photophobia than did those without TVDs. Suicidal ideation and suicide attempts were more common among patients with than among those without TVDs [ideation: odds ratio (OR) = 1.92, 95% confidence interval (CI) 1.71-2.15, p < 0.001; suicide attempt: OR = 2.23, 95% CI 1.80-2.75, p < 0.001].ConclusionThe presence of TVDs may imply greater migraine-related disability, photophobia, and suicidal ideation/suicide attempt risk in patients with MO.Copyright © 2023, the Chinese Medical Association.

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