• Medicine · Mar 2023

    Meta Analysis

    Effect of duloxetine on pain relief after total knee arthroplasty: A meta-analysis of randomized controlled trials.

    • Lu-Kai Zhang, Qiang Li, Yan-Fen Fang, and Ji-Wei Qi.
    • Department of Orthopedics, Xiaoshan Traditional Chinese Medical Hospital, Hangzhou, Zhejiang Province, People's Republic of China.
    • Medicine (Baltimore). 2023 Mar 10; 102 (10): e33101e33101.

    BackgroundPostoperative pain is one of the most feared complications of total knee arthroplasty. Recently, randomized controlled trials have compared the efficacy of duloxetine in patients undergoing total knee arthroplasty. However, there is no definite answer as to the efficacy and safety of duloxetine.MethodsRandomized controlled trials about relevant studies were searched from PubMed (1996 to July 2022), Embase (1996 to July 2022), and Cochrane Library (CENTRAL, July 2022).ResultsSix high-quality studies containing 532 patients met the inclusion criteria. Results show patients in the duloxetine group had better performance in terms of visual analog scale (P < .05), equivalent morphine consumption (P < .05), and length of stay (P < .05).ConclusionDuloxetine can be used to reduce pain after knee arthroplasty in selected patients.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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