• Anesthesia and analgesia · Apr 2023

    Understanding Outcomes After Major Surgery.

    • David Alexander Harvie, Denny Zelda Hope Levett, and GrocottMichael Patrick WilliamMPWNIHR Southampton Biomedical Research Centre, University Hospital Southampton/University of Southampton, Southampton, United Kingdom..
    • From the Department of Anaesthesia & Perioperative Care and General Intensive Care Unit, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.
    • Anesth. Analg. 2023 Apr 1; 136 (4): 655664655-664.

    AbstractThe global volume of surgery is increasing. Adverse outcomes after surgery have resource implications and long-term impact on quality of life and consequently represent a significant and underappreciated public health issue. Standardization of outcome reporting is essential for evidence synthesis, risk stratification, perioperative care planning, and to inform shared decision-making. The association between short- and long-term outcomes, which persists when corrected for base-line risk, has significant implications for patients and providers and warrants further investigation. Candidate mechanisms include sustained inflammation and reduced physician activity, which may, in the future, be mitigated by targeted interventions.Copyright © 2023 International Anesthesia Research Society.

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