• Julia Loewenthal, Kim E Innes, Margalit Mitzner, Carol Mita, and Ariela R Orkaby.
• Division of Aging, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts (J.L.).
• Ann. Intern. Med. 2023 Apr 1; 176 (4): 524535524-535.

BackgroundYoga, a multicomponent mind-body practice, improves several domains of physical and psychological health and may affect frailty in older adults.PurposeTo evaluate the available trial evidence on the effect of yoga-based interventions on frailty in older adults.Data SourcesMEDLINE, EMBASE, and Cochrane Central from their inception to 12 December 2022.Study SelectionRandomized controlled trials evaluating the effect of yoga-based interventions, including at least 1 session of physical postures, on a validated frailty scale or single-item markers of frailty in adults aged 65 years or older.Data ExtractionTwo authors independently screened articles and extracted data; 1 author assessed risk of bias with review from a second author. Disagreements were resolved through consensus and as-needed input from a third author.Data SynthesisThirty-three studies (n = 2384 participants) were identified in varied populations, including community dwellers, nursing home residents, and those with chronic disease. Yoga styles were primarily based on Hatha yoga and most often included Iyengar or chair-based methods. Single-item frailty markers included measures of gait speed, handgrip strength, balance, lower-extremity strength and endurance, and multicomponent physical performance measures; no studies included a validated definition of frailty. When compared with education or inactive control, there was moderate-certainty evidence that yoga improved gait speed and lower-extremity strength and endurance, low-certainty evidence for balance and multicomponent physical function measures, and very low-certainty evidence for handgrip strength.LimitationHeterogeneity in study design and yoga style, small sample sizes, and reporting deficiencies leading to concerns for selection bias.ConclusionYoga may affect frailty markers that are associated with clinically meaningful outcomes in older adult populations but may not offer benefit over active interventions (for example, exercise).Primary Funding SourceNone. (PROSPERO: CRD42020130303).

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