• Nicole D Ford, Carla L DeSisto, Romeo R Galang, Elena V Kuklina, Laurence S Sperling, and Jean Y Ko.
• Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia (N.D.F., C.L.D., R.R.G.).
• Ann. Intern. Med. 2023 Apr 1; 176 (4): 472479472-479.

BackgroundEstimates of cardiac arrest occurring during delivery guide evidence-based strategies to reduce pregnancy-related death.ObjectiveTo investigate rate of, maternal characteristics associated with, and survival after cardiac arrest during delivery hospitalization.DesignRetrospective cohort study.SettingU.S. acute care hospitals, 2017 to 2019.ParticipantsDelivery hospitalizations among women aged 12 to 55 years included in the National Inpatient Sample database.MeasurementsDelivery hospitalizations, cardiac arrest, underlying medical conditions, obstetric outcomes, and severe maternal complications were identified using codes from the International Classification of Diseases, 10th Revision, Clinical Modification. Survival to hospital discharge was based on discharge disposition.ResultsAmong 10 921 784 U.S. delivery hospitalizations, the cardiac arrest rate was 13.4 per 100 000. Of the 1465 patients who had cardiac arrest, 68.6% (95% CI, 63.2% to 74.0%) survived to hospital discharge. Cardiac arrest was more common among patients who were older, were non-Hispanic Black, had Medicare or Medicaid, or had underlying medical conditions. Acute respiratory distress syndrome was the most common co-occurring diagnosis (56.0% [CI, 50.2% to 61.7%]). Among co-occurring procedures or interventions examined, mechanical ventilation was the most common (53.2% [CI, 47.5% to 59.0%]). The rate of survival to hospital discharge after cardiac arrest was lower with co-occurring disseminated intravascular coagulation (DIC) without or with transfusion (50.0% [CI, 35.8% to 64.2%] or 54.3% [CI, 39.2% to 69.5%], respectively).LimitationsCardiac arrests occurring outside delivery hospitalizations were not included. The temporality of arrest relative to the delivery or other maternal complications is unknown. Data do not distinguish cause of cardiac arrest, such as pregnancy-related complications or other underlying causes among pregnant women.ConclusionCardiac arrest was observed in approximately 1 in 9000 delivery hospitalizations, among which nearly 7 in 10 women survived to hospital discharge. Survival was lowest during hospitalizations with co-occurring DIC.Primary Funding SourceNone.

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