• Leonardo S Lino-Silva, Raúl Hernández-Romero, Juan S García-Herrera, César Zepeda-Najar, Rosa A Salcedo-Hernández, Alberto M León-Takahashi, Marín G Escobar-Jiménez, and Ángel Herrera-Gómez.
• Department of Oncological Pathology, Instituto Nacional de Cancerología, Mexico City.
• Gac Med Mex. 2023 Jan 1; 159 (1): 384338-43.

IntroductionAppropriate size of resection margins in acral melanoma is not clearly established.ObjectiveTo investigate whether narrow-margin excision is appropriate for thick acral melanoma.MethodsThree-hundred and six patients with acral melanoma were examined. Factors associated with recurrence and survival were analyzed according to surgical margin size (1 to 2 cm and > 2 cm).ResultsOut of 306 patients, 183 were women (59.8%). Median Breslow thickness was 6 mm; 224 cases (73.2%) were ulcerated, 154 patients (50.3%) had clinical stage III disease, while 137 were at stage II (44.8%) and 15 at stage IV (4.9%). All cases had negative margins, with a median of 31.5 mm. A Breslow thickness of 7 mm (p = 0.001) and clinical stage III (p = 0.031) were associated with recurrence; the factors associated with survival were Breslow index (p = 0.047), ulceration (p = 0.003), advanced clinical stage (p < 0.001), and use of adjuvant therapy (p = 0.003).ConclusionA resection margin of 1 to 2 cm did not affect tumor recurrence or survival in patients with acral melanoma.Copyright: © 2023 Permanyer.

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