• J. Cardiothorac. Vasc. Anesth. · Feb 2010

    Review Meta Analysis

    Reducing mortality in cardiac surgery with levosimendan: a meta-analysis of randomized controlled trials.

    • Giovanni Landoni, Anna Mizzi, Giuseppe Biondi-Zoccai, Giovanna Bruno, Elena Bignami, Laura Corno, Massimo Zambon, Chiara Gerli, and Alberto Zangrillo.
    • Department of Cardiothoracic Anesthesia and Intensive Care, Università Vita-Salute San Raffaele, Istituto Scientifico San Raffaele, Via Olgettina 60, Milano 20132, Italy. landoni.giovanni@hsr.it
    • J. Cardiothorac. Vasc. Anesth. 2010 Feb 1;24(1):51-7.

    ObjectivesThe authors performed a meta-analysis to evaluate whether levosimendan is associated with improved survival in patients undergoing cardiac surgery.DesignA meta-analysis.SettingHospitals.ParticipantsA total of 440 patients from 10 randomized controlled studies were included in the analysis.InterventionsNone. MEASURMENTS AND MAIN RESULTS: Four investigators independently searched BioMedCentral and PubMed. Inclusion criteria were random allocation to treatment, comparison of levosimendan versus control, and cardiac surgery patients. Exclusion criteria were duplicate publications, nonhuman experimental studies, and no mortality data. The primary endpoint was postoperative mortality. Levosimendan was associated with a significant reduction in postoperative mortality (11/235 [4.7%] in the levosimendan group v 26/205 [12.7%] in the control arm, odds ratio = 0.35 [0.18-0.71], p for effect = 0.003, p for heterogeneity = 0.22, I(2) = 27.4% with 440 patients included), cardiac troponin release, and atrial fibrillation. No difference was found in terms of myocardial infarction, acute renal failure, time on mechanical ventilation, intensive care unit, and hospital stay.ConclusionsLevosimendan has cardioprotective effects that could result in a reduced postoperative mortality. A large randomized controlled study is warranted in this setting.Copyright 2010 Elsevier Inc. All rights reserved.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…