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- Haoran Zheng, Fan Yang, Kaige Deng, Jiaxin Wei, Zhenting Liu, Yong-Chang Zheng, and Haifeng Xu.
- Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.
- Medicine (Baltimore). 2023 Mar 17; 102 (11): e33225e33225.
AbstractIron is essential to organisms, the liver plays a vital role in its storage. Under pathological conditions, iron uptake by the intestine or hepatocytes increases, allowing excess iron to accumulate in liver cells. When the expression of hepcidin is abnormal, iron homeostasis in humans cannot be regulated, and resulting in iron overload. Hepcidin also regulates the release of iron from siderophores, thereby regulating the concentration of iron in plasma. Important factors related to hepcidin and systemic iron homeostasis include plasma iron concentration, body iron storage, infection, inflammation, and erythropoietin. This review summarizes the mechanism and regulation of iron overload caused by hepcidin, as well as related liver diseases caused by iron overload and treatment.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.
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