• Yang Meng, Liao Chifeng, Zhu Qinghuan, Huang Zichan, Li Jianmin, and Deng Danqi.
• Department of Dermatology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
• Medicine (Baltimore). 2023 Mar 17; 102 (11): e29652e29652.

BackgroundTo systematically evaluate the clinical risk factors of patients with systemic lupus erythematosus (SLE) complicated with invasive fungal infection (IFI) among patients.MethodsA meta-analysis was performed of all the literatures germane to estimate the clinical risk factors of patients with SLE complicated with IFI from published clinical trials from 1990 to April 2022. Mean differences, odds ratio and 95% confidence intervals were calculated, and the meta-analysis was conducted with Stata 12.0 software (StataCorp, College Station, TX).ResultsA total of 14 clinical research involving 1129 patients were included. The results of meta-analysis demonstrated that immunosuppressant, glucocorticoids, systemic lupus erythematosus disease activity index score, antibiotic were risk factors associated with IFI in SLE patients. However, age, sex, course of disease, leukopenia, lymphopenia, C- reactive protein and hypoproteinemia were not the risk factors associated with IFI in patients with SLE.ConclusionOur results indicate that immunosuppressant, glucocorticoids, systemic lupus erythematosus disease activity index score, antibiotic were risk factors for IFI in SLE patients. However, high quality of multicenter, large sample size-controlled trials are needed to validate the result.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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