• Hadrien Rozé, Abdelghani Lafrikh, Virginie Perrier, Arnaud Germain, Antoine Dewitte, Francis Gomez, Gérard Janvier, and Alexandre Ouattara.
• Department of Anesthesia and Intensive Care II, Thoracic Intensive Care Unit, Centre Hospitalier Universitaire Bordeaux, Groupe Sud, Pessac, Université Victor Segalen Bordeaux II, Bordeaux, France. hadrien.roze@chu-bordeaux.fr
• Intensive Care Med. 2011 Jul 1;37(7):1087-94.

PurposeTo determine the feasibility of daily titration of the neurally adjusted ventilatory assist (NAVA) level in relation to the maximal diaphragmatic electrical activity (EAdi(maxSBT)) measured during a spontaneous breathing trial (SBT) during pressure support ventilation (PSV).MethodsThe study included 15 consecutive patients in whom mechanical ventilation weaning was initiated with the NAVA mode. EAdi(maxSBT) was determined daily during an SBT using PSV with 7 cmH2O of inspiratory pressure and no positive end-expiratory pressure (PEEP). If the SBT was unsuccessful, NAVA was used and the level was then adjusted to obtain an EAdi of ~60% of the EAdi(maxSBT). Arterial blood gas analyses were performed 20 min after each change in NAVA level.ResultsThree patients were dropped from the study at day 4 because of worsening of their sickness. The median duration of NAVA ventilation was 4.5 days (IQR 3-6.5). From day 1 to extubation, EAdi(maxSBT) and EAdi increased significantly from 16.6 (9.6) to 21.7 (10.3) μV (P = 0.013) and from 10.0 (5.5) to 15.1 (9.2) μV (P = 0.026), respectively. The pressure delivered significantly decreased from 20 (8) to 10 (5) cmH2O (P = 0.003). Conversely, tidal volume, carbon dioxide tension, and pH values remained unchanged during the same period.ConclusionThese results suggest that daily titration of NAVA level with an electrical goal of ~60% EAdi(maxSBT) is feasible and well tolerated. The respiratory mechanics improvement and increase in respiratory drive allowed for a daily reduction of the NAVA level while preserving breathing, oxygenation, and alveolar ventilation until extubation.

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