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Editorial Comment Meta Analysis
Importance of sequential methods in meta-analysis: implications for postoperative mortality, delirium, and stroke management.
- Thomas Payne, Ben Moran, John Loadsman, Ian Marschner, Tim McCulloch, and Robert D Sanders.
- Central Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia; Department of Anaesthetics, Royal Prince Alfred Hospital, Sydney Local Health District, Sydney, NSW, Australia.
- Br J Anaesth. 2023 Apr 1; 130 (4): 395401395-401.
AbstractTrial sequential analysis is an adaptation of frequentist sequential methods that can be used to improve inferences from meta-analysis. Trial sequential analysis can help preserve type I and type II error rates at desired levels for analyses conducted before the required information size. Through three case studies recently published in the British Journal of Anaesthesia, we show how trial sequential analysis can inform the interpretation of meta-analyses. Limitations of trial sequential analysis, which also include those of the meta-analysis to which it is applied, must be carefully considered alongside its benefits.Copyright © 2023 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.
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