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- Susumu Naito, Shuichiro Higo, Satoshi Kameda, Shou Ogawa, Tomoka Tabata, Yasuhiro Akazawa, Daisuke Nakamura, Kei Nakamoto, Fusako Sera, Yuki Kuramoto, Yoshihiro Asano, Shungo Hikoso, Shigeru Miyagawa, and Yasushi Sakata.
- Faculty of Medicine, Osaka University, Japan.
- Intern. Med. 2023 Nov 1; 62 (21): 316731733167-3173.
AbstractThe MYH7 R453 variant has been identified in inherited hypertrophic cardiomyopathy (HCM) and is associated with sudden death and a poor prognosis. The detailed clinical course of HCM with the MYH7 R453 variant, from a preserved to a reduced left ventricular ejection fraction, has not been reported. We identified the MYH7 R453C and R453H variants in three patients who progressively developed advanced heart failure requiring circulatory support and summarized the clinical course and echocardiographic parameters of these patients over the years. Because of the rapid disease progression, we consider genetic screening for patients with HCM imperative for future prognosis stratification.
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