• Internal medicine · Nov 2023

    Case Reports

    A Rare Case of Blindness Caused by Syphilis with Malignant Hypertensive Nephropathy.

    • Minami Matsumoto, Shinya Yamamoto, Takuya Morinishi, Eishin Harima, Shintaro Nakayasu, Nobuki Iwamoto, Yuki Muraoka, Ayako Takahashi, Sachiko Minamiguchi, and Motoko Yanagita.
    • Department of Nephrology, Kyoto University, Japan.
    • Intern. Med. 2023 Nov 1; 62 (21): 319532013195-3201.

    AbstractThe number of patients with syphilis has been rapidly increasing. Without treatment, syphilis can damage various organs and become life-threatening. We herein report a 29-year-old woman diagnosed with neurosyphilis, acute hydrocephalus, syphilitic uveitis combined with hypertensive retinopathy, and malignant hypertensive nephropathy. To our knowledge, this is the first report of syphilis complicated with malignant hypertensive nephropathy proven by a renal biopsy. Neurosyphilis was successfully treated with intravenous penicillin G, and severe hypertension subsequently resolved. However, delayed medical examinations and complications of syphilitic uveitis and hypertensive retinopathy resulted in irreversible visual loss. To prevent irreversible organ damage, early treatment is essential.

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