• Mesut Mısırlıoğlu, İzzet Bingöl, Coşkun Genç, Aylin Akbulut, Mert Ocak, Neziha Yağmur Diker, Ahmet Özmeriç, Gökhan Koca, Melike Bahçecitapar, Mehmet Şenes, Ayşegül Fırat, Fevziye Figen Kaymaz, Hakan Hamdi Çelik, İffet İrem Çankaya, and Meliha Korkmaz.
• Department of Orthopedics and Traumatology, University of Health Sciences Ankara Oncology Education and Training Hospital, Ankara, Turkey.
• Turk J Med Sci. 2023 Feb 1; 53 (1): 293929-39.

BackgroundWe have evaluated the effects of taurine and aqueous garlic extract (AGE) as a dietary supplement on osteoporotic fracture (OPF) healing in the ovariectomized rat femur fracture model.MethodsIn this experimental animal study,twenty-four osteoporosis-remodeled female Wistar albino rats were randomly divided into 3 groups (n: 8) according to their supplemented diet; control, taurine, and AGE groups. Unilateral femur middiaphysis mini-open osteotomy was stabilized with Kirschner wires. Six weeks after osteotomy, the rats were sacrificed before the femurs were harvested and OPF healing was evaluated with biochemical, histologic, microcomputed-tomography, and scintigraphic methods.ResultsAs an indicator of the antiosteoporotic effect, the calcium levels of the taurine group were significantly lower than the AGE and control groups in biochemical analyzes (p < 0.01). In histological studies, the new bone diameter and new bone volume values of the taurine group were significantly higher than the control group (p = 0.002 and p = 0.032, respectively), while higher trabecular-compact callus was observed in the taurine and AGE groups, respectively, compared to the control group. In morphological analyses, taurine and AGE groups had significantly higher bone volume/tissue volume, trabecular number, bone surface density, and lower trabecular separation than the control group (p < 0.05). The scintigraphic imaging showed a significant increase in osteoblastic activity of the taurine group compared to the control group (p = 0.005).DiscussionTaurine and AGE have positive anabolic effects, respectively, on the healing of OPFs, demonstrated by biochemical, histological, morphological, and scintigraphic methods.

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