• Hakan Düğer, Muhammed Kızılgül, Pınar Akhanlı, Murat Çalapkulu, Hayrı Bostan, Sema Hepşen, Ümran Gül, Muhammed Erkam Sencar, Erman Çakal, and Bekir Uçan.
• Health Sciences University, Dışkapı Yıldırım Beyazit Training and Research Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey.
• Turk J Med Sci. 2023 Feb 1; 53 (1): 303309303-309.

BackgroundNodular thyroid disease is a frequent finding seen in patients with acromegaly. Ultrasound-elastography (US-E) appears to be a helpful tool for the diagnosis of thyroid cancer. The aims of this study were to evaluate thyroid nodules in acromegaly and to assess the diagnostic accuracy of US-E in detecting thyroid cancer in this population.MethodsUS-E was applied to 166 nodules detected in 102 acromegalic patients and to 105 nodules found in 95 nonacromegalic subjects. The lesions were classified according to the elasticity scores (ES) as soft (ES 1-2) or hard (ES 3-4).Results: Mean age was 55.1 ± 12.47 years [59 (58%) women]. The prevalence of hard nodules (ES 3 and 4) was significantly higher in the group of acromegalic patients than in control subjects (48% to 20%, p < 0.001). Mean ES was higher in patients with acromegaly (2.45 to 2.22, p: 0.001), however, the mean strain index (SI) was similar between groups (1.53 to 1.65, p: 0.204).DiscussionThyroid nodules in acromegaly patients have a higher elasto score and the prevalence of hard nodules is higher in active disease. However, increased stiffness of nodules by US-E in patients with acromegaly does not seem to estimate the malignancy of the nodules.

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