• Beatrice Mahler, Oana Andreea Parliteanu, Octavian Alexe, Corina Rîșcă Popazu, Catalina Elena Ene, Bogdan Timar, and Tudor Constantinescu.
• National Institute of Pneumology Marius Nasta, 050159 Bucharest, Romania.
• Medicina (Kaunas). 2023 Mar 11; 59 (3).

IntroductionCOVID-19 infection is often associated with a vast spectrum of opportunistic bacterial and fungal infections. Herein, we share a summary of the first case of COVID-19-associated mucormycosis (CAM) in a patient from Romania.Case PresentationA 51-year-old male non-smoker, with no known relevant medical history, who denied any previous alcohol use and was vaccinated against COVID-19 (complete scheme with Vaxzevria), was admitted to the hospital for severe COVID-19 infection. The first mucormycosis-related symptoms were reported on the eighth day of admission and were followed by the rapid deterioration of the patient's condition and, consequently, death. The main aggravating factors, which were identified to be associated with the development of mucormycosis and with the poor outcome, were the association of severe COVID-19, new-onset COVID-19-triggered type 2 diabetes, and corticoid treatment for severe COVID-19.ConclusionThe association between severe COVID-19 and newly diagnosed type 2 diabetes, triggered by COVID-19 infection, increases the risk of severe opportunistic fungal infections and the associated mortality rates.

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