• Critical care medicine · Aug 2023

    Multicenter Study Observational Study

    The Role of Cell Cycle Arrest Biomarkers for Predicting Acute Kidney Injury in Critically Ill COVID-19 Patients: A Multicenter, Observational Study.

    • Raphael Weiss, Thilo von Groote, Marlies Ostermann, Nuttha Lumlertgul, Kittisak Weerapolchai, GarciaManuel Ignacio MongeMIMDepartment of Critical Care Medicine, University Hospital SAS de Jerez, Jerez de la Frontera, Spain., Jose Maria Martin Cano, Del CorralBeatriz DiezBDDepartment of Critical Care Medicine, University Hospital SAS de Jerez, Jerez de la Frontera, Spain., María Jesús Broch-Porcar, Marcos Perez Carrasco, Arsenio De la Vega Sanchez, Eduardo Sousa, Ana Catarino, Antonio Jorge Betbesé Roig, Jaume Baldira Martinez de Irujo, Silvia de Rosa, Manuel Garcia-Montesinos de la Peña, Teresa Tomasa, Matteo Brivio, Francisco Javier Gonzalez De Molina, Joachim Gerss, John A Kellum, Carola Wempe, Anna Leidereiter, Melanie Meersch, and Alexander Zarbock.
    • Department of Anesthesiology, Intensive Care Medicine and Pain Medicine, University Hospital Münster, Münster, Germany.
    • Crit. Care Med. 2023 Aug 1; 51 (8): 9921000992-1000.

    ObjectivesPatients with COVID-19-associated acute respiratory distress syndrome (ARDS) have a high risk for developing acute kidney injury (AKI) which is associated with an increased risk of death and persistent renal failure. Early prediction of AKI is crucial in order to implement preventive strategies. The purpose of this study was to investigate the predictive performance of tissue inhibitor of metalloproteinases 2 and insulin like growth factor binding protein 7 (TIMP-2) × (IGFBP7) in critically ill patients with COVID-19-associated ARDS.DesignMulticenter, prospective, observational study.SettingTwelve centers across Europe and United Kingdom.PatientsPatients with moderate or severe COVID-19-associated ARDS were included and serial measurements of (TIMP-2) × (IGFBP7) were performed.InterventionsNone.Measurements And Main ResultsThe primary endpoint was the development of moderate or severe AKI according to the Kidney Disease: Improving Global Outcomes definition. Three hundred patients were available for the primary analysis, and 39 met the primary endpoint. At enrollment, urinary (TIMP-2) × (IGFBP7) had high predictive value for the primary endpoint with an area under the receiver operating characteristic curve of 0.89 (95% CI, 0.84-0.93). (TIMP-2) × (IGFBP7) was significantly higher in endpoint-positive patients at enrollment and at 12 hours.ConclusionsUrinary (TIMP-2) × (IGFBP7) predicts the occurrence of AKI in critically ill patients with COVID-19-associated ARDS.Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine and Wolters Kluwer Health, Inc.

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