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- Menglu Chen, Lailai Li, Yihui Chai, Yuqi Yang, Sibu Ma, Xiang Pu, and Yunzhi Chen.
- Guizhou University of Traditional Chinese Medicine, Guiyang City, Guizhou Province, China.
- Medicine (Baltimore). 2023 Mar 31; 102 (13): e33417e33417.
AbstractThe etiology of premature ovarian failure (POF) is mainly related to inflammatory diseases, autoimmune diseases, and tumor radiotherapy and chemotherapy; however, its specific pathogenesis has not been clarified. Vitamin D (VD), a fat-soluble vitamin, is an essential steroid hormone in the human body. Neutrophil extracellular traps (NETs) are meshwork structures that are formed when neutrophils are stimulated by inflammation and other factors and are closely associated with autoimmune and inflammatory diseases. Notably, VD inhibits NET formation and intervenes in the development of POF in terms of inflammatory and immune responses, oxidative stress, and tissue fibrosis. Therefore, this study aimed to theorize the relationship between NETs, VD, and POF and provide new ideas and targets for the pathogenesis and clinical treatment of POF.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.
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