• Aili Yu, Hong Liu, Haiyan Yu, and Xue Xiong.
• Department of Cardiovascular Medicine, Chengdu Eighth People's Hospital (Geriatric Hospital of Chengdu Medical College), Sichuan, China.
• Medicine (Baltimore). 2023 Mar 31; 102 (13): e33383e33383.

BackgroundThe management of acute myocardial infarction (AMI) has improved dramatically over the past 3 decades and is evolving. Percutaneous coronary intervention is an alternative means of achieving coronary revascularization. Previous studies comparing the published literature on drug-coated balloon (DCB) and drug-eluting stents have drawn divergent conclusions. We perform a protocol for systematic review and meta-analysis to compare the efficacy and safety of DCB and drug-eluting stent in the management of AMI.MethodsThis systematic review was registered in the PROSPERO network (registration number: CRD42023397266). We will follow the Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocol to accomplish the systematic review protocol. A systematic search will be conducted in PubMed, Embase, Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure, Wanfang Database, and Weipu Database without any language restrictions from their inception to February 2022. The risk of bias will be assessed independently by 2 authors using parameters defined in the Cochrane Handbook for Systematic Reviews of Interventions criteria. Statistical analysis will be performed using the STATA13.0 software (IBM, USA).ResultsThe results of this systematic review and meta-analysis will be publicly available and published in a peer-reviewed journal.ConclusionThe results of the study will provide the evidence for the application of DCB in the treatment of AMI.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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