• J Formos Med Assoc · Oct 2023

    Observational Study

    Safety and efficacy of early varenicline prescription in hospitalized patients with acute myocardial infarction: East Asian population.

    • Chien-Hsien Lo, Li-Ching Li, Kai-Wei Chang, Chin-Feng Tsai, Chun-Hung Su, Tse-Hsien Lo, Chi-Hua Yen, and Kuei-Chuan Chan.
    • Institute of Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Division of Cardiology, Department of Internal Medicine, Chung-Shan Medical University Hospital, Taichung, Taiwan.
    • J Formos Med Assoc. 2023 Oct 1; 122 (10): 103510411035-1041.

    BackgroundSmoking is a strong risk factor for patients with acute myocardial infarction (AMI). Varenicline is commonly used as a smoking cessation medication, but little is known about its usage in patients with AMI, particularly in hospitalized patients.MethodsThis is a prospective observational, single-center study collected from May 2018 to July 2021. Study patients underwent percutaneous coronary intervention for AMI. The primary end point was set as safety of varenicline, focusing on any serious adverse cardiac events within 24 weeks after treatment. Efficacy of smoking abstinence was also assessed through self-reports of complete abstinence over a week before the 24- week clinic visit.ResultsA total of 162 patients hospitalized with AMI were enrolled in our study. Mean age was 56.7 ± 9.95 years and 97% of the patients were male. Most patients (93.2%) received their first dose of varenicline during hospitalization. Time from admission to first dose of study medication was 2.31 ± 2.73 days and duration of drug intake was 7.41 ± 5.18 weeks. At week 24, only one patient had recurrent myocardial infarction, five patients had undergone revascularization for target lesion failure, and no additional patients developed stroke or died. In terms of efficacy, the rate of smoking abstinence was 79%. Light smokers found it easier to quit smoking than heavy smokers.ConclusionThis study may represent the first report on the safety and efficacy of early initiation of varenicline treatment in East Asian population hospitalized due to AMI who recently underwent percutaneous coronary intervention.Copyright © 2023. Published by Elsevier B.V.

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