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- Hisanori Utsunomiya, Yoichi Akazawa, Hiroya Ueyama, Tomoyo Iwano, Momoko Yamamoto, Ryota Uchida, Shotaro Oki, Nobuyuki Suzuki, Daiki Abe, Atsushi Ikeda, Tsutomu Takeda, Kumiko Ueda, Mariko Hojo, Yukinori Yube, Sanae Kaji, Soh Okano, Sho Tsuyama, Hidetaka Eguchi, Yasushi Okazaki, Masami Arai, Tetsu Fukunaga, Takashi Yao, and Akihito Nagahara.
- Department of Gastroenterology, Juntendo University School of Medicine, Japan.
- Intern. Med. 2023 Nov 15; 62 (22): 333333393333-3339.
AbstractAlthough gastric juvenile polyposis (GJP) often coexists with gastric cancer, a preoperative accurate diagnosis is still difficult to obtain. A 70-year-old woman was referred for epigastralgia and anemia. Esophagogastroduodenoscopy with a conventional endoscope showed numerous gastric polyps with no cancerous findings. Magnifying endoscopy with narrow-band imaging (M-NBI) showed cancerous findings, and a target biopsy revealed adenocarcinoma. Histopathological findings after endoscopic resection confirmed a diagnosis of juvenile polyposis with intramucosal adenocarcinoma. Genetic analyses revealed a germline pathogenic variant of SMAD4. A target biopsy using M-NBI and endoscopic resection proved useful for confirming the preoperative diagnosis of coexisting cancerous lesions in GJP.
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