• Internal medicine · Nov 2023

    Case Reports

    Efficacy of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor Treatment for Repeated In-stent Restenosis in a Coronary Artery.

    • Takumi Akiyama, Kazuyuki Ozaki, Toshiki Takano, Shintaro Yoneyama, Naoki Kubota, Takeshi Okubo, Ryutaro Ikegami, Makoto Hoyano, Takao Yanagawa, and Takayuki Inomata.
    • Department of Cardiovascular Medicine, Niigata University Graduate School of Medical and Dental Sciences, Japan.
    • Intern. Med. 2023 Nov 15; 62 (22): 336133653361-3365.

    AbstractA 57-year-old woman experienced chest pain. A coronary angiogram revealed middle left anterior descending artery stenosis. Despite receiving adequate anti-hyperlipidemia treatment and undergoing percutaneous coronary intervention (PCI), she experienced angina and required PCI six more times for in-stent restenosis. As she had high lipoprotein (a) [LP-(a)] levels at the seventh PCI procedure, proprotein convertase subtilisin/kexin type 9 inhibitor (PCSK9i) was administered, and a reduction in the LP-(a) and low-density lipoprotein cholesterol (LDL-C) values was observed. She experienced no recurrence of angina for five years with PCSK9i treatment. PCSK9i can reduce not only LDL-C but also LP-(a) levels, resulting in cardiac event risk reduction.

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