• Internal medicine · Nov 2023

    Case Reports

    Pneumocystis Pneumonia Infection Following the Initiation of Pembrolizumab Therapy for Lung Adenocarcinoma: A Case Report.

    • Toshiyuki Sumi, Kazuya Takeda, Haruhiko Michimata, Daiki Nagayama, Yuta Koshino, Hiroki Watanabe, Yuichi Yamada, Kentaro Kodama, Hirotaka Nishikiori, and Hirofumi Chiba.
    • Department of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, Japan.
    • Intern. Med. 2023 Nov 15; 62 (22): 338133853381-3385.

    AbstractPneumocystis pneumonia (PCP) is an opportunistic infection that presents a ground-glass appearance in the lungs on chest radiography. Interstitial lung disease is a commonly reported adverse effect of immune checkpoint inhibitor (ICI) treatment; however, there are few reports of ICI treatment-associated PCP infection. A 77-year-old man with lung adenocarcinoma was administered pembrolizumab and hospitalized for dyspnea 2 weeks after treatment. Chest computed tomography showed bilateral ground-glass opacities in all lung lobes. PCP was therefore diagnosed, and steroids and sulfamethoxazole-trimethoprim were initiated. Following treatment, the patient's condition improved promptly. This report suggests that ICI treatment can cause PCP infection.

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