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Review Case Reports
Clinical Characteristics of Retroviral Rebound Syndrome: A Case Report and Literature Review.
- Yu Akagi, Kosuke Tanaka, Momoko Mawatari, Yuta Toda, Toshio Kumasaka, and Akihiro Ueda.
- Department of Infectious Diseases, Japanese Red Cross Medical Center, Japan.
- Intern. Med. 2023 Jan 1; 62 (7): 108910931089-1093.
AbstractWe herein report a case of retroviral rebound syndrome (RRS) complicated with hemophagocytic lymphohistiocytosis. Owing to the paucity of comprehensive data on RRS, we also conducted a literature review. All 19 cases included in the review presented within 2 months after the discontinuation of antiretroviral therapy. They were usually accompanied by both a significant decrease in CD4 count (median 292/μL) and a rapid increase in plasma human immunodeficiency virus loads (median 3.5×105/mL). Although life-threatening complications were reported, the overall prognosis was favorable. The outcomes of this review aided in the diagnosis of the present case.
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