• Med. Clin. North Am. · May 2023

    Review

    Hepatic Manifestations of Systemic Diseases.

    • Humberto C Gonzalez and Stuart C Gordon.
    • Division of Gastroenterology and Hepatology, Henry Ford Health, 2799 West Grand Boulevard, Detroit, MI 48202, USA; Wayne State University School of Medicine, 540 E Canfield St, Detroit, MI 48201, USA. Electronic address: hgonzal1@hfhs.org.
    • Med. Clin. North Am. 2023 May 1; 107 (3): 465489465-489.

    AbstractIn addition to being the primary target of infections such as viral hepatitis, the liver may also be affected by systemic disease. These include bacterial, mycotic, and viral infections, as well as autoimmune and infiltrative diseases. These conditions generally manifest as abnormal liver biochemistries, often with a cholestatic profile, and may present with additional signs/symptoms such as jaundice and fever. A high index of suspicion and familiarity with potential causal entities is necessary to guide appropriate testing, diagnosis, and treatment.Copyright © 2023 Elsevier Inc. All rights reserved.

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