• Med. Clin. North Am. · May 2023

    Review

    Alcoholic Hepatitis: The Rising Epidemic.

    • Pranav Penninti, Ayooluwatomiwa D Adekunle, and Ashwani K Singal.
    • Division of Gastroenterology and Hepatology, University of Texas Health San Antonio, TX, USA.
    • Med. Clin. North Am. 2023 May 1; 107 (3): 533554533-554.

    AbstractAlcoholic hepatitis (AH) is a unique clinical syndrome on the spectrum of alcohol-associated liver disease (ALD). It constitutes a rising epidemic with increasing incidence and major public health implications. In severe AH, 30-day mortality approaches 30%, yet therapeutic options remain limited. Survival benefit from corticosteroids, the mainstay of medical treatment, is short-lived. Among corticosteroid nonresponders, the use of early liver transplantation is heterogeneous across centers and remains limited by significant barriers. Long-term prognosis is largely dictated by abstinence; however, comorbid alcohol use disorder remains undertreated. Efforts to address these challenges are required to curb the AH epidemic.Copyright © 2022 Elsevier Inc. All rights reserved.

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