• Med. Clin. North Am. · May 2023

    Review

    Sarcopenia and Frailty in Cirrhosis: Assessment and Management.

    • Chalermrat Bunchorntavakul.
    • Division of Gastroenterology and Hepatology, Department of Medicine, Rajavithi Hospital, College of Medicine, Rangsit University, 2 Phaya Thai Road, Ratchathewi, Bangkok 10400, Thailand. Electronic address: dr.chalermrat@gmail.com.
    • Med. Clin. North Am. 2023 May 1; 107 (3): 589604589-604.

    AbstractSarcopenia and frailty are frequent in cirrhosis, and both contribute to increased morbidity and mortality. The complex pathogenesis of sarcopenia in cirrhosis is mainly determined by hyperammonemia and malnutrition. Sarcopenia/frailty screening and reevaluation should be undertaken in all cirrhotic patients. Frailty tests are useful in the ambulatory setting, whereas the computed tomography scan is the diagnostic gold standard for sarcopenia. To manage sarcopenia/frailty, a multidisciplinary team should develop a personalized comprehensive care plan that includes patient education, protein/calorie intake goals, late evening meals, exercise programs, and micronutrient replenishment. In selected patients, branched-chain amino acid and testosterone supplements may also be beneficial.Copyright © 2022 Elsevier Inc. All rights reserved.

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