• Xiaole Guo, Weiwan Yang, Ying Wang, Shiqi Ma, Qi Lu, and Hongfeng Wang.
• Department of Acupuncture and Tui Na, Changchun University of Chinese Medicine, Changchun, China.
• Medicine (Baltimore). 2023 Apr 7; 102 (14): e33490e33490.

BackgroundSleep deprivation often lead to changes in attention, memory, mood, alertness, and metabolism. Especially, it is often accompanied by cognitive impairment of the brain. Acupuncture is safe and effective for improving cognitive function, but its underlying mechanism is not fully understood. Resting-state functional magnetic resonance imaging is an important means to study brain activity changes. However, the results are inconsistent and lack systematic evaluation and analysis.MethodsWe will search 9 databases, including PubMed, EMBASE, EBSCOhost-Medline, Web of Science, Cochrane Library, China National Knowledge Infrastructure, VIP Database and Wan-Fang Database, Chinese Biomedical Literature Database, and 2 clinical trials register platforms: Chinese Clinical Trial Registry, ClinicalTrials.gov (www.ClinicalTrials.gov/) from inception to November 1, 2022. We will use the Review Manager 5.4 software provided by the Cochrane Collaborative Network for statistical analysis. We then assessed the quality and risk of the included studies and observed the outcome measures.ResultsThis study will analyze the effect of acupuncture on brain activity changes, improvement of sleep duration, and cognitive impairment.ConclusionThis meta-analysis aims to investigate the efficacy of acupuncture on brain activity changes in sleep deprivation comorbid with cognitive dysfunction, so as to provide effective evidence for clarifying its pathogenesis.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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