• Rauf Oguzhan Kum, Fatma Cemre Sazak Kundi, Canan Topcuoglu, and Muge Ozcan.
• Department of Otorhinolaryngology, Ankara City Hospital, Ankara, Turkey. adigerok@yahoo.com.tr.
• Ir J Med Sci. 2023 Dec 1; 192 (6): 290929152909-2915.

BackgroundApnea-related hypoxia, hypercapnia, and blood pressure fluctuations cause production of various proinflammatory cytokines and trigger a vicious cycle that results in vascular endothelial damage and systemic inflammation in obstructive sleep apnea (OSA). Endothelial function is frequently impaired in OSA even in the absence of significant cardiac or vascular disorders.AimsThis study aimed to investigate the serum endocan and serglycin levels in OSA patients.MethodsThis prospective study included 78 consecutive patients who admitted to the sleep laboratory of a tertiary referral center with the complaints of daytime sleepiness, witnessed sleep apnea, and/or snoring and who underwent all-night polysomnography (PSG). After PSG, the patients were divided into four groups in relation with their apnea-hypopnea indexes. The groups were compared for endocan and serglycin levels and their correlations with OSA severity. The correlations with demographic data and PSG findings were also investigated.ResultsThe OSA and the control groups had significantly different endocan and serglycin levels ([Formula: see text], for both). On univariate logistic regression analysis, it was found that serglycin and endocan levels and BMI were predictors of OSA. Multiple logistic regression analysis showed that endocan and serglycin levels were independent predictors for OSA ([Formula: see text] and [Formula: see text], respectively).ConclusionsWe have demonstrated that elevated endocan and serglycin levels are predictors for OSA. Furthermore, we have showed for the first time in literature that serglycin is correlated with OSA and is an independent predictor for OSA.© 2023. The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland.

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