• Havva Çobanogullari, EvrenEmine UnalEUDepartment of Clinical Microbiology and Infectious Diseases, Faculty of Medicine, University of Kyrenia, Kyrenia, Cyprus; Department of Medical Genetics, Faculty of Medicine, Near East University, Nicosia, Cyprus., Hakan Evren, Kaya Suer, Ozlem Balcioglu, and Mahmut Cerkez Ergoren.
• Department of Molecular Medicine, Institute of Graduate Studies, Near East University, Nicosia, Cyprus; Department of Medical Genetics, Faculty of Medicine, Near East University, Nicosia, Cyprus.
• Med Clin (Barc). 2023 Jun 9; 160 (11): 489494489-494.

Background And ObjectivesThe COVID-19 pandemic that emerged in China in late 2019 and spread rapidly around the world. There is evidence that COVID-19 infection can be influenced by genetic variations in the host. The aim of this study was to investigate the association between ACE InDel polymorphism and COVID-19 in Northern Cyprus.Patients And MethodsThis study included 250 patients diagnosed with COVID-19 and 371 healthy controls. Genotyping for the ACE InDel gene polymorphism was performed by polymerase chain reaction.ResultsThe frequency of ACE DD homozygotes was significantly increased in COVID-19 patients compared to the control group (p=0.022). The difference in the presence of the D allele between the patient and control groups was statistically significant (57.2% and 50.67%, respectively, p<0.05). Individuals with the genotype II were found to have a higher risk of symptomatic COVID-19 (p=0.011). In addition, chest radiographic findings were observed more frequently in individuals with the genotype DD compared to individuals with the genotypes ID and II (p=0.005). A statistically significant difference was found when the time of onset of symptoms for COVID-19 and duration of treatment were compared with participants' genotypes (p=0.016 and p=0.014, respectively). The time of onset of COVID-19 was shorter in individuals with the genotype DD than in individuals with the genotype II, while the duration of treatment was longer.ConclusionIn conclusion, the ACE I/D polymorphism has the potential to predict the severity of COVID-19.Crown Copyright © 2023. Published by Elsevier España, S.L.U. All rights reserved.

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