• Internal medicine · Nov 2023

    Review Case Reports

    Pancreatic Mixed Acinar-neuroendocrine-ductal Carcinoma: A Case Report and Literature Review.

    • Ryohei Sakaguchi, Reiko Yamada, Kenji Nose, Takamitsu Tanaka, Yumi Murashima, Junya Tsuboi, and Hayato Nakagawa.
    • Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Japan.
    • Intern. Med. 2023 Nov 15; 62 (22): 334733533347-3353.

    AbstractPancreatic mixed neoplasms are very rare. We herein report a unique case of pancreatic mixed acinar-neuroendocrine-ductal carcinoma with trilineage differentiation. The patient was an 83-year-old woman referred to our hospital due to anemia and a pancreatic mass. Contrast-enhanced computed tomography revealed a 60-mm mass in the pancreas. Subtotal stomach-preserving pancreaticoduodenectomy was performed. The postoperative pathological diagnosis was mixed acinar-neuroendocrine-ductal carcinoma. Postoperative chemotherapy was conducted according to the adenocarcinoma and neuroendocrine carcinoma protocols. The patient died 26 months postoperatively. Choosing appropriate chemotherapy for mixed neoplasms is difficult. Cancer gene panel testing, if possible, may support the choice of therapeutic agents.

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