• Jessica Tarn, Evelyn Evans, Emmanuella Traianos, Alexis Collins, Mryto Stylianou, Jehill Parikh, Yang Bai, Yu Guan, James Frith, Dennis Lendrem, Victoria Macrae, Iain McKinnon, Bruce S Simon, Justyna Blake, Mark R Baker, John Paul Taylor, Stuart Watson, Peter Gallagher, Andrew Blamire, Julia Newton, and Wan-Fai Ng.
• Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
• Neuromodulation. 2023 Apr 1; 26 (3): 681689681-689.

ObjectivesFatigue is one of the most important symptoms needing improvement in Primary Sjögren's syndrome (PSS). Previous data from our group suggest that noninvasive stimulation of the vagus nerve (nVNS) may improve symptoms of fatigue. This experimental medicine study uses the gammaCore device (electroCore) and a sham device to investigate the relationship between nVNS and fatigue in PSS, and to explore potential mechanisms involved.Materials And MethodsForty participants with PSS were randomly assigned to use active (n = 20) or sham (n = 20) nVNS devices twice daily for 54 days in a double-blind manner. Patient-reported measures of fatigue were collected at baseline and day 56: Profile of Fatigue (PRO-F)-Physical, PRO-F-Mental and Visual Analogue Scale of abnormal fatigue (fVAS). Neurocognitive tests, immunologic responses, electroencephalography alpha reactivity, muscle acidosis, and heart rate variability were compared between devices from baseline to day 56 using analysis of covariance.ResultsPRO-F-Physical, PRO-F-Mental, and fVAS scores were significantly reduced at day 56 in the active group only (p = 0.02, 0.02, and 0.04, respectively). Muscle bioenergetics and heart rate variability showed no change between arms. There were significant improvements in digit span and a neurocognitive test (p = 0.03), and upon acute nVNS stimulation, frontal region alpha reactivity showed a significant negative relationship with fatigue scores in the active group (p < 0.01).ConclusionsWe observed significant improvements in three measures of fatigue at day 56 with the active device but not the sham device. Directly after device use, fatigue levels correlate with measures of alpha reactivity, suggesting modulation of cholinergic system integrity as a mechanism of action for nVNS.Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

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