• Yang Long and Yuxi Zhang.
• Department of Pharmacy, Jintang First People's Hospital (West China Hospital Sichuan University Jintang Hospital), Chengdu, 610041, People's Republic of China.
• Ir J Med Sci. 2023 Dec 1; 192 (6): 280928142809-2814.

AimTo assess clinical efficacy and safety of liraglutide combined with metformin (LMT) in obese patients with type 2 diabetes (ODP) by conducting a meta-analysis of randomized controlled trials (RCTs).MethodsPubMed, EMBASE, Cochrane Library, CNKI, CNKI, and VIP databases were systematically searched for randomized controlled trials (RCTs) through January 1, 2015 to investigate the effectiveness of liraglutide combined with metformin treatment (LMT) in obesity patients with type 2 diabetes (ODP). Meta-analysis (using generic inverse variance random effects model) was performed when there were two or more studies reporting on the same evaluation indicators. Review Manager V.5.3 was used to perform the meta-analysis.ResultsA total of 1289 participants from 15 RCTs were selected for the final meta-analysis. A synthesis of current evidence of LMT for treating ODP was provided in this protocol.ConclusionThis review will offer insights for future research and provide reference for LMT treatment for ODP.© 2023. The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland.

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