• Lin Zhao, Chuan Chang, Yan Zhuang, Binbin Wang, Lang Qin, Jia-Jun Zheng, Yong-Ping You, Ning Liu, Jing Ji, and Kang Zheng.
• Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
• World Neurosurg. 2023 Jul 1; 175: e841e854e841-e854.

ObjectiveTo investigate prognostic factors in patients with primary skull base chordoma (PSBC) to guide future therapeutic advances.MethodsThis retrospective cohort study of 94 PSBC patients was conducted in 2 institutions from January 2006 to December 2013. Independent predictors for progression-free survival (PFS) and overall survival were established with multivariate Cox regression analysis.ResultsAge (P = 0.006), extent of resection (P = 0.037), and radiotherapy (RT) (P = 0.027) were established as independent predictors for PFS in PSBC patients. Similarly, age (P = 0.002), extent of resection (P = 0.048), and RT (P = 0.015) were established as independent predictors for overall survival. Meta-analysis manifested that lower MIB-1 correlated with longer PFS in skull base chordoma patients (P < 0.001). RT doubled the 5-year PFS rate from 28.6 ± 12.1% to 61.6 ± 10.7% (P = 0.031) and increased the 5-year overall survival rate from 54.5 ± 13.8% to 84.2 ± 8.4% (P = 0.020) in the subtotal resection/partial resection and MIB-1 labeling index (STR/PR+MIB-1 LI) <2% subgroup. In contrast, in the STR/PR+MIB-1 LI ≥2% subgroup, the survival benefit of RT remained uncertain. Further analysis revealed no survival difference between different RT modalities in STR/PR PSBC patients.ConclusionsIn PSBC patients, age, extent of resection, and adjuvant RT all are independent predictors for PFS. Lower MIB-1 LI is associated with longer PFS in PSBC patients. Adjuvant RT is necessary for PSBC patients who undergo STR/PR with MIB-1 LI <2%. Patients who undergo GTR or STR/PR with MIB-1 LI ≥2% seem nonresponsive to RT.Copyright © 2023 Elsevier Inc. All rights reserved.

19 keywords...

hide…