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- Chihiro Takai, Kayo Misumi, Daiki Kaito, Hiroaki Nishida, Masami Yoshii, So Yamada, Takaomi Kobayashi, Toshitaka Koinuma, Takashi Kadoya, Takuya Kimura, Yoshihiro Hagiwara, and Takayuki Ogura.
- Department of Emergency and Critical Care, Saiseikai Utsunomiya Hospital, Japan.
- Intern. Med. 2023 Apr 15; 62 (8): 118511891185-1189.
AbstractLacosamide is an antiepileptic drug that acts on voltage-gated sodium channels and was approved as an antiepileptic by the Food and Drug Administration in 2008. Although the efficacy and safety of lacosamide have been established in many previous trials, some case reports have shown that it may lead to cardiovascular side effects, especially in patients with electrical conduction system disorders. We herein report a case of life-threatening cardiac arrhythmia caused by lacosamide intoxication that was successfully treated with veno-arterial extracorporeal membrane oxygenation.
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