• Internal medicine · Dec 2023

    Case Reports

    Branch-duct Intraductal Papillary Mucinous Neoplasm with Rapidly Developing Intracystic Xanthogranulomatous Nodules.

    • Sho Kitagawa, Shin Ichihara, Yuko Omori, Chiho Maeda, Yusuke Ono, Munenori Tahara, Toru Furukawa, Shunji Muraoka, and Hiroyuki Miyakawa.
    • Department of Gastroenterology, Sapporo Kosei General Hospital, Japan.
    • Intern. Med. 2023 Dec 1; 62 (23): 348934943489-3494.

    AbstractWe herein report a case of a branch-duct intraductal papillary mucinous neoplasm (IPMN) with rapidly developing intracystic xanthogranulomatous nodules. A unilocular cystic lesion without a mural nodule was found in the pancreatic tail of a 69-year-old man. Ten months later, multiple mural nodules emerged unexpectedly within the cyst, and the patient underwent distal pancreatectomy. Based on immunohistochemical studies and a molecular analysis, we diagnosed him with branch-duct IPMN of the gastric immunophenotype. Fragility of the pancreatic duct mucosa and consequent exposure of the wall to pancreatic juice might have caused marked granulation nodule formation in the cyst lumen.

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