• Internal medicine · Dec 2023

    Case Reports

    The Evaluation of Benzodiazepine-induced Dysphagia using High-resolution Manometry: A Case Report.

    • Kenjiro Kunieda, Yuichi Hayashi, Megumi Yamada, Shohei Nishida, Ryusuke Moribayashi, Tomohisa Ohno, Ichiro Fujishima, Akio Kimura, and Takayoshi Shimohata.
    • Department of Neurology, Gifu University Graduate School of Medicine, Japan.
    • Intern. Med. 2023 Dec 1; 62 (23): 353735403537-3540.

    AbstractWe evaluated the pathophysiology of dysphagia considered to be induced by benzodiazepine using high-resolution manometry (HRM). A 53-year-old man with Parkinson disease had had dysphagia for over 3 months. He had been taking several benzodiazepines for more than four years. Two weeks after discontinuation of the benzodiazepines, HRM revealed increased pharyngeal contractility and residual pressure at the upper esophageal sphincter. A video-fluoroscopic swallowing study showed improved pharyngeal bolus passage. Benzodiazepine-induced dysphagia may be due to the muscle relaxant effects on the swallowing muscles and attenuation of the barrier function which prevents reflux from the esophagus into the pharynx.

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