• Medicine · Apr 2023

    In silico structure-based design of peptides or proteins as therapeutic tools for obesity or diabetes mellitus: A protocol for systematic review and meta analysis.

    • Isaiane Medeiros, Ana Júlia Felipe Camelo Aguiar, Wendjilla Medeiros Fortunato, Ana Francisca Gomes Teixeira, Emilly Guedes Oliveira E Silva, Ingrid Wilza Leal Bezerra, Juliana Kelly da Silva Maia, Grasiela Piuvezam, and MoraisAna Heloneida de AraújoAHA0000-0002-6460-911Biochemistry and Molecular Biology Postgraduate Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.Nutrition Postgraduate Program, Center for Health Sciences, Federal.
    • Biochemistry and Molecular Biology Postgraduate Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
    • Medicine (Baltimore). 2023 Apr 14; 102 (15): e33514e33514.

    BackgroundIn silico studies using dynamic simulation or molecular docking have boosted the screening and identification of molecules and/or targets in studies aimed at treating diseases such as obesity and diabetes mellitus, optimizing the development of new drugs. This study aims to describe a systematic review protocol on peptides and proteins evaluated in silico as potential therapeutic agents for obesity or diabetes mellitus.MethodsThis protocol followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses Protocols and was registered in the International Prospective Register of Systematic Reviews database (number: CRD42022355540). The databases to be searched will be PubMed, ScienceDirect, Scopus, Web of Science, virtual health library, and EMBASE. It will be included in silico studies that evaluate the simulation by dynamics or molecular docking of proteins or peptides involved in treating obesity or diabetes mellitus. Two independent reviewers will select studies, extract data, and assess methodological quality using the adapted Strengthening the reporting of empirical simulation studies. A narrative synthesis of the included studies will be performed for the systematic reviews.ResultsThis protocol contemplates the production of 2 systematic reviews to be developed focusing on obesity or diabetes mellitus.ConclusionThe reviews will enable knowledge of peptides and proteins involved in research treating these diseases and will emphasize the importance of in silico studies in this context and for the development of future studies.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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