• Xue Li, Min Jing, Yanbo Dai, and Xiaoming Xing.
• Department of Pathology, First People's Hospital of Neijiang, Neijiang, China.
• Medicine (Baltimore). 2023 Apr 14; 102 (15): e33500e33500.

RationaleTumor to tumor metastasis is a rare phenomenon clinically, especially tumor to meningioma metastasis. Here, we present an unusual case of metastasis of nasopharyngeal carcinoma to meningioma.Patient ConcernsA 55-year-old man, with a history of nasopharyngeal carcinoma, developed neurological symptoms.DiagnosisComputed tomography and magnetic resonance imaging revealed a mass on left temporoparietal lobe, indicating the presence of meningioma. The pathologist diagnosed the metastasis of nasopharyngeal carcinoma (differentiated non-keratinizing squamous cell carcinoma) to meningioma.InterventionsChemotherapy and immunotherapy were performed following the resection.OutcomesThe patient has been well and no relapses has been observed.LessonsDoctors should be aware of the presence of tumor-to-tumor metastasis, which is a rare phenomenon. A positive history of primary extracranial tumor should raise the suspicion of potential tumor-to-tumor metastasis.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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