• Am. J. Med. Sci. · Jul 2023

    Review

    Efficacy and safety of intravenous leukotriene receptor antagonists in acute asthma.

    • Shaya Yaanallah Al Qahtani.
    • Department of Internal Medicine and Critical Care Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia. Electronic address: saalQahthani@iau.edu.sa.
    • Am. J. Med. Sci. 2023 Jul 1; 366 (1): 222622-26.

    AbstractThe incidence of bronchial asthma has increased substantially since recent decades in both children and adults. Moreover, the number of patients presenting with asthma exacerbation to the emergency department has also increased in several countries. Leukotrienes are inflammatory mediators that play an important role in bronchial asthma exacerbation. Leukotriene receptor antagonists reduce asthma exacerbation in chronic asthma; moreover, the current guidelines for asthma management recommend the use of oral leukotriene receptor antagonists for asthma control and reduce further exacerbation. However, data on the use of intravenous leukotriene receptor antagonists during acute asthma exacerbation are scarce. Nevertheless, currently available data revealed a trend of significant improvement of acute asthma and rapid reversal of airflow obstruction when administered during an acute asthma attack. This review aims to summarize currently available data on the use of intravenous leukotriene receptor antagonists in adult patients with acute asthma exacerbation.Copyright © 2023 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.

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