• Singapore medical journal · Dec 2024

    Review

    Localised swelling at sites of dermal filler injections following administration of Covid-19 vaccines: a systematic review.

    • Chew Lip Ng, Evelyn Yuxin Tay, and Alwyn Ray D'Souza.
    • Department of Otolaryngology-Head and Neck Surgery, Ng Teng Fong General Hospital, Singapore.
    • Singapore Med J. 2024 Dec 1; 65 (12): 665668665-668.

    IntroductionLocalised swelling at sites of filler injections has been reported in the Moderna mRNA-1273 coronavirus disease 2019 (COVID-19) vaccine trial.MethodsWe conducted a review of the existing data and literature on the potential pathophysiology for this adverse event and its potential management.ResultsData from the Moderna and Pfizer COVID-19 vaccine Phase 3 trial and one case series were available. Three out of 30,400 subjects developed possible filler reaction in the Moderna trial. Two other cases were reported after emergency use authorisation. Reactions occurred at a mean of 1.4 days post-vaccination. Fillers were injected at a mean of 14.1 months before vaccination. Areas involved included lips, infraorbital areas and tear troughs. Treatment included observation, corticosteroids, antihistamine, hyaluronidase and 5-fluorouracil.ConclusionRare, self-limiting adverse reactions to dermal fillers have been reported following COVID-19 vaccination. Clinicians should be aware of this clinical phenomenon and its management, as vaccination is carried out globally.Copyright © 2023 Singapore Medical Journal.

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