• Stefano Fresilli, Rosa Labanca, Fabrizio Monaco, Alessandro Belletti, Filippo D'Amico, Andrea Blasio, Yuki Kotani, Giovanni Landoni, and Del Nido Study Group.
• Department of Cardiothoracic and Vascular Surgery, IRCCS San Raffaele Scientific Institute, Milan, Italy.
• J. Cardiothorac. Vasc. Anesth. 2023 Jul 1; 37 (7): 115211591152-1159.

ObjectiveTo compare the outcomes of patients receiving del Nido solution versus any other type of cardioplegia.DesignA systematic review and meta-analysis of randomized trials.SettingCardiac operating rooms.ParticipantsAdult patients (≥18 years old) undergoing cardiac surgery.InterventionsThe EMBASE, MEDLINE, and CENTRAL databases were searched systematically from their inception until August 2022 for randomized controlled trials comparing del Nido versus other cardioplegias.Measurements And Main ResultsTen studies were included, including 1,812 patients (871 in the del Nido group and 941 in the control group), and published after 2017. There were significant reductions in postoperative stroke and/or transient ischemic attack rate in the del Nido group: 9/467 (1.9%) v 25/540 (4.6%); odds ratio (OR), 0.43; 95% CI, 0.20-0.92 (p = 0.007). Del Nido cardioplegia was also associated with significantly shorter aortic cross-clamp time (mean difference, -8.99 minutes; 95% CI, -17.24 to -0.73 [p < 0.001]), significantly reduced need for defibrillation (89/582 [15%] v 252/655 [38%]; OR, 0.33; 95% CI, 0.15-0.72 [p < 0.001]), significantly lower risk of postoperative acute kidney injury (21/235 [8.9%] v 34/301 [11%]; OR, 0.50; 95% CI, 0.26-0.97 [p = 0.04]), with no effect on mortality (14/607 [2.3%] v 12/681 [1.8%]; p = 0.5).ConclusionAccording to the authors' meta-analysis of recent randomized clinical trials, del Nido is a safe cardioplegic solution, which might provide better organ protection in adult cardiac surgery without differences in mortality when compared to other cardioplegic solutions.Copyright © 2023 Elsevier Inc. All rights reserved.

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