• Martha F Kienzle, Ryan W Morgan, Jessica S Alvey, Ron Reeder, Robert A Berg, Vinay Nadkarni, Alexis A Topjian, Javier J Lasa, Tia T Raymond, Robert M Sutton, and American Heart Association's Get With The Guidelines®-Resuscitation Investigators.
• Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States. Electronic address: kienzlem@chop.edu.
• Resuscitation. 2023 Jul 1; 188: 109807109807.

AimsThe primary objective was to determine the association between clinician-reported use of end-tidal CO2 (ETCO2) or diastolic blood pressure (DBP) to monitor cardiopulmonary resuscitation (CPR) quality during pediatric in-hospital cardiac arrest (pIHCA) and survival outcomes.DesignA retrospective cohort study was performed in two cohorts: (1) Patients with an invasive airway in place at the time of arrest to evaluate ETCO2 use, and (2) patients with an arterial line in place at the time of arrest to evaluate DBP use. The primary exposure was clinician-reported use of ETCO2 or DBP. The primary outcome was return of spontaneous circulation (ROSC). Propensity-weighted logistic regression evaluated the association between monitoring and outcomes.SettingHospitals reporting to the American Heart Association's Get With The Guidelines®- Resuscitation registry (2007-2021).PatientsChildren with index IHCA with an invasive airway or arterial line at the time of arrest.ResultsBetween January 2007 and May 2021, there were 15,280 pediatric CPR events with an invasive airway or arterial line in place at the time of arrest. Of 7159 events with an invasive airway, 6829 were eligible for analysis. Of 2978 events with an arterial line, 2886 were eligible. Clinicians reported using ETCO2 in 1335/6829 (20%) arrests and DBP in 1041/2886 (36%). Neither exposure was associated with ROSC. ETCO2 monitoring was associated with higher odds of 24-hour survival (aOR 1.17 [1.02, 1.35], p = 0.03).ConclusionsNeither clinician-reported ETCO2 monitoring nor DBP monitoring during pIHCA were associated with ROSC. Monitoring of ETCO2 was associated with 24-hour survival.Copyright © 2023. Published by Elsevier B.V.

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