• Aliye Çelikkol, Aykut Demirkıran, Cihan Aydın, Aydın Akyüz, Mustafa Kaplangöray, Ahsen Yılmaz, Muhammed Mucip Efe, and Savaş Güzel.
• Tekirdağ Namık Kemal Üniversitesi, Faculty of Medicine, Department of Medical Biochemistry - Tekirdağ, Turkey.
• Rev Assoc Med Bras (1992). 2023 Jan 1; 69 (4): e20221254e20221254.

ObjectiveIn this article, we investigated the association of chromogranin A with coronary artery disease.MethodsBiochemical parameters and chromogranin A levels obtained from peripheral blood samples during coronary angiography were analyzed in 90 patients. Patients were classified into two groups, namely, SYNergy between PCI with TAXUS and Cardiac Surgery score ≥1 (n=45) and SYNergy between PCI with TAXUS and Cardiac Surgery score=0 (n=45). This is a cross-sectional, prospective study.ResultsSerum chromogranin A levels were significantly higher in the group with SYNergy between PCI with TAXUS and Cardiac Surgery score ≥1 compared to the group with SYNergy between PCI with TAXUS and Cardiac Surgery score=0 (1381.5±418.9 ng/mL and 1121.2±290.7 ng/mL, respectively; p=0.002). Serum chromogranin A levels were correlated with SYNergy between PCI with TAXUS and Cardiac Surgery score (r=0.556, p<0.04). ROC analysis showed that the area under the curve for serum chromogranin A levels was 0.687 (p=0.007), and the best cutoff value of 1,131 ng/mL had a sensitivity of 67% and a specificity of 65% for the prediction of coronary artery disease.ConclusionSerum chromogranin A levels were increased in coronary artery disease patients with SYNergy between PCI with TAXUS and Cardiac Surgery score ≥1. Increasing serum chromogranin A levels are proportional to the SYNergy between PCI with TAXUS and Cardiac Surgery score.

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